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Results for "

Gram-positive strain

" in MedChemExpress (MCE) Product Catalog:

42

Inhibitors & Agonists

11

Peptides

9

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1174
    Bekanamycin

    Kanamycin B

    		 Antibiotic Bacterial Infection
    Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain .
    Bekanamycin
  • HY-163331
    Cresomycin

    		Antibiotic Bacterial Infection
    Cresomycin is a bridged macrobicyclic antibiotic that can bind to the bacterial ribosome. Cresomycin exhibits efficacy against both Gram-positive and Gram-negative bacteria, including multidrug-resistant strains of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa .
    Cresomycin
  • HY-154861
    Anticancer agent 118

    		Bacterial Apoptosis Necroptosis
    Anticancer agent 118, a N‑acylated ciprofloxacin derivative, has anti-bacterial and anticancer activities. Anticancer agent 118 shows high activity against Gram-positive strains and antiproliferative activities against prostate PC3 cells. Anticancer agent 118 can be used for antitumor research .
    Anticancer agent 118
  • HY-P5706
    HG2

    		Bacterial Infection Inflammation/Immunology
    HG2 is a fast-acting antimicrobial peptide. HG2 shows anti-biofilm and anti-inflammatory activities. HG2 is active against Gram-positive pathogens, especially against MRSA strains (MIC: 16-32?μg/mL). HG2 can bind to bacterial lipids and reduces ATP concentration in S. aureus MRSA USA300 cells .
    HG2
  • HY-P5709
    HG4

    		Bacterial Infection Inflammation/Immunology
    HG4 is a fast-acting antimicrobial peptide. HG4 shows anti-biofilm and anti-inflammatory activities. HG4 is active against Gram-positive pathogens, especially against MRSA strains (MIC: 32-64?μg/mL). HG4 can bind to bacterial lipids and reduces ATP concentration in S. aureus MRSA USA300 cells .
    HG4
  • HY-B0960
    Sulfabenzamide

    N-Sulfanilylbenzamide

    		 Autophagy Bacterial Antibiotic Infection
    Sulfabenzamide (N-Sulfanilylbenzamide) is an antimicrobial agent and usually consumed in combination with Sulfathiazole and Sulfacetamide. Sulfabenzamide is effective against Gram-positive and negative bacterial strains .
    Sulfabenzamide
  • HY-155007
    DNA gyrase B-IN-2

    		Bacterial Infection
    DNA gyrase B-IN-2 (Compound E) is a 2-aminobenzothiazole-based DNA gyrase B inhibitor with promising activity against ESKAPE bacterial pathogens. DNA gyrase B-IN-2 showed low nanomolar inhibition of DNA gyrase (IC50 < 10 nM) and broad-spectrum antibacterial activity against pathogens belonging to the ESKAPE group, with the minimum inhibitory concentration < 0.03 μg/mL for most Gram-positive strains and 4–16 μg/mL against Gram-negative E. coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.DNA gyrase B-IN-2 can be used for the research of infection .
    DNA gyrase B-IN-2
  • HY-P5740
    Cacaoidin

    		Bacterial Infection
    Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .
    Cacaoidin
  • HY-A0086
    Netilmicin sulfate

    SCH-20569 sulfate

    		 Bacterial Antibiotic Infection
    Netilmicin (sulfate) (SCH-20569 (sulfate)) is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin.
    Netilmicin sulfate
  • HY-136295
    Quinaldopeptin

    		Antibiotic Bacterial Infection Inflammation/Immunology
    Quinaldopeptin, a quinomycin antibiotic isolated from the culture of Streptoverticillium album strain, is highly active against Gram-positive bacteria and anaerobes and strongly cytotoxic against cultured B16 melanoma cells .
    Quinaldopeptin
  • HY-125414
    Lydicamycin

    		Antibiotic Bacterial Infection
    Lydicamycin is an antibiotic isolated from the fermentation broth of an actinomycete strain identified as Streptomyces lydicus. Lydicamycin is active against Gram-positive bacteria and a certain yeast, but inactive against Gram-negative bacteria .
    Lydicamycin
  • HY-105387
    Heliquinomycin

    		DNA/RNA Synthesis Bacterial Topoisomerase Infection Cancer
    Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth .
    Heliquinomycin
  • HY-146470
    Antibacterial agent 103

    		Bacterial Infection
    Antibacterial agent 103 (compound 7) has highly antibacterial activity against kinds of Gram-positive and -negative bacteria. Antibacterial agent 103 can be used for researching inhibition of resistance bacterial strains .
    Antibacterial agent 103
  • HY-149379
    DNA gyrase B-IN-3

    		Bacterial DNA/RNA Synthesis Infection
    DNA gyrase B-IN-3 (Compound A) is a bacterial DNA gyrase B inhibitor (IC50: < 10 nM). DNA gyrase B-IN-3 has antibacterial activity against gram-positive strains .
    DNA gyrase B-IN-3
  • HY-P5546
    Lynronne-2

    		Bacterial Infection
    Lynronne-2 is an antimicrobial peptide. Lynronne-1 is active against Gram-positive bacterials, including MDR strains (MIC: 32-256 μg/mL for methicillin-resistant MRSA strains). Lynronne-2 is also effective against P. aeruginosa infection
    Lynronne-2
  • HY-P5547
    Lynronne-3

    		Bacterial Infection
    Lynronne-3 is an antimicrobial peptide. Lynronne-1 is active against Gram-positive bacterials, including MDR strains (MIC: 32-128 μg/mL for methicillin-resistant MRSA strains). Lynronne-3 is also effective against P. aeruginosa infection
    Lynronne-3
  • HY-153429
    WU-FA-01

    		Bacterial Infection
    WU-FA-01, a hydrogenated derivative of WU-FA-00, is an antibacterial agent that exhibits high levels of antibacterial activity against Gram-positive strains and also has some anti-inflammatory activity .
    WU-FA-01
  • HY-P5695
    GP-2B

    		Bacterial Infection
    GP-2B is an antimicrobial peptide. GP-2B shows antibacterial activity against Gram-positive strain (MIC: 8-128 μg/mL for S. aureus and Enterococcus faecalis) .
    GP-2B
  • HY-A0276A
    Gentamicin

    		Antibiotic Bacterial Infection
    Gentamicin, an orally active aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM .
    Gentamicin
  • HY-125524
    Antibacterial agent 199

    		Bacterial Infection
    Antibacterial agent 199 (Compound 2) is an activator for caseinolytic protease (ClpP) with a Kd of 0.7 μM. Antibacterial agent 199 exhibits antibacterial efficacy against Gram-positive strains Staphylococcus aureus, Streptococcus pneumoniae and Gram-negative strain Neisseria meningitidis, with MICs of 16, 0.5 and 0.5 μg/mL, respectively .
    Antibacterial agent 199
  • HY-A0276
    Gentamicin sulfate
    Maximum Cited Publications
    23 Publications Verification

    		 Bacterial Antibiotic Infection Cancer
    Gentamicin sulfate, an orally active aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC50 of 0.57 mM .
    Gentamicin sulfate
  • HY-N3138
    Ombuoside

    		Bacterial Infection
    Ombuoside is a glycoside ombuoside isolated from Gynostemma pentaphyllum.Ombuoside has antimicrobial activity against several strains of gram-positive and gram-negative bacteria and the yeast Candida albicans . Ombuoside has antioxidant effects by scavenging free radicals and ROS .
    Ombuoside
  • HY-B0593
    Ceftazidime
    15+ Cited Publications

    GR20263

    		 Beta-lactamase Bacterial Antibiotic Infection
    Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
    Ceftazidime
  • HY-P5545
    Lynronne-1

    		Bacterial Infection
    Lynronne-1 is an antimicrobial peptide. Lynronne-1 is active against Gram-positive bacterials, including MDR strains (MIC: 8-32 μg/mL for methicillin-resistant MRSA strains). Lynronne-1 reduces the bacterial load in MRSA infected wound murine model. Lynronne-1 is also effective against P. aeruginosa infection .
    Lynronne-1
  • HY-B0593A
    Ceftazidime pentahydrate
    15+ Cited Publications

    GR20263 pentahydrate
    Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .
    Ceftazidime pentahydrate
  • HY-79635
    Methyl indole-3-carboxylate

    		Bacterial Infection
    Methyl indole-3-carboxylate is a natural product isolated from Sorangium cellulosum strain Soce895. Methyl indole-3-carboxylate shows a weak activity against the Gram-positive Nocardia sp with a MIC value of 33.33 μg/mL .
    Methyl indole-3-carboxylate
  • HY-P3328
    MDP1

    		Bacterial Infection
    MDP1, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa .
    MDP1
  • HY-P3328A
    MDP1 acetate

    		Bacterial Infection
    MDP1 acetate, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 acetate has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa .
    MDP1 acetate
  • HY-B1286
    Piperacillin sodium
    5 Publications Verification

    Sodium piperacillin

    		 Bacterial Antibiotic Penicillin-binding protein (PBP) Infection
    Piperacillin sodium is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam .
    Piperacillin sodium
  • HY-B1923
    Piperacillin
    5 Publications Verification

    Pipracil
    Piperacillin is a semisynthetic broad-spectrum β-lactam antibiotic which exhibits potent bactericidal activity against Gram-negative bacteria as well as select Gram-positive strains through penicillin-binding proteins. Piperacillin is most commonly used in combination with the β-lactamase inhibitor Tazobactam .
    Piperacillin
  • HY-149925
    DNA Gyrase-IN-6

    		Bacterial DNA/RNA Synthesis Topoisomerase Infection
    Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor .
    DNA Gyrase-IN-6
  • HY-13234
    Rifaximin
    1 Publications Verification

    		 Bacterial Antibiotic DNA/RNA Synthesis Infection Cancer
    Rifaximin, a gastrointestinal-selective antibiotic, binds the β-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of bacterial RNA synthesis. Rifaximin susceptibility is higher against Gram-positive strains (MIC: 0.03-5 mg/ml) compared to Gram-negative bacteria (MIC: 8-50 mg/mL) .
    Rifaximin
  • HY-119789
    Albofungin

    		Antibiotic Bacterial Infection
    Albofungin (Antibiotic P-42-1) is isolated from the culture filtrate of Actinomyces tumemacerans strain INMI.P-42. Albofungin shows highly active on a wide variety of gram-positive bacteria and fungi. Albofungin shows cytotoxic to HeLa cell cultures and exhibited antitumor activity on EHRLICH ascites tumor in mice.
    Albofungin
  • HY-125733
    Thiocillin I

    		Bacterial Antibiotic Infection
    Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively .
    Thiocillin I
  • HY-133119
    PK150

    		Bacterial Infection
    PK150, an analogue of Sorafenib, shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 µM, respectively .
    PK150
  • HY-160669
    Antibacterial agent 198

    		Bacterial Infection
    Antibacterial agent 198 (Compound 16) is an antibacterial agent against gram positive Staphylococcus aureus and strains of Entercoccus .
    Antibacterial agent 198
  • HY-125728
    Micrococcin P1

    		Bacterial Parasite HCV Infection
    Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC50 range of 0.1-0.5 μM . Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against S. aureus 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively . Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum .
    Micrococcin P1
  • HY-N10282
    Isodihydroauroglaucin

    		Fungal Bacterial Endogenous Metabolite Infection
    Isodihydroauroglaucin, a fungal metabolite, shows antibacterial activity .
    Isodihydroauroglaucin
  • HY-N8461
    Reuterin

    3-Hydroxypropionaldehyde; 3-Hydroxypropanal

    		 Bacterial Infection
    Reuterin is a broad-spectrum antimicrobial agent active against Gram positive and Gram negative bacteria, as well as yeasts, moulds and protozoa. Reuterin is produced by specific strains of Lactobacillus reuteri during anaerobic metabolism of glycerol. Reuterin also demonstrates potent antimicrobial activity against a broad panel of human and poultry meat campylobacter spp. Isolates .
    Reuterin
  • HY-B0960S
    Sulfabenzamide-d4

    N-Sulfanilylbenzamide-d4

    		 Bacterial Autophagy Antibiotic Isotope-Labeled Compounds Others
    Sulfabenzamide-d4 is the deuterium labeled Thiabendazole.
    Sulfabenzamide-d4
  • HY-P5710
    LCI peptide

    		Bacterial Infection
    LCI peptide is an antimicrobial peptide with antibacterial activity. LCI peptide is active against plant pathogens, Xanthomonas and Pseudomonas, including E. coli, Gentamicin-resistant MRSA and Xoo .
    LCI peptide
  • HY-P5557
    TP4 (Nile tilapia piscidin)

    		Bacterial Necroptosis Cancer
    TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide. TP4 inhibits multiple gram positive and negative strains (MIC: 0.03-10 μg/mL). TP4 shows hemolytic activities. TP4 enhances immune response, antioxidant activity, and intestinal health against bacterial infections. TP4 also has anti-tumor effect, and induces necrosis by triggering mitochondrial dysfunction in cancer cells .
    TP4 (Nile tilapia piscidin)

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